Proteomics in Molecular Toxicology: Identification of Potential Early Protein Biomarkers for Hepatocarcinogenicity in Rats

  • K. Fella Merck KGaA, Institute of Toxicology,
  • M. Glückmann Applied Biosystems, Darmstadt, Germany
  • V. Kruft Applied Biosystems, Darmstadt, Germany
  • P.-J. Kramer Merck KGaA, Institute of Toxicology,
  • M. Kröger Merck KGaA, Institute of Toxicology,

Abstrakt

Modern proteomics technology was used for identification of protein biomarkers for hepatocarcinogenicity. It replaced currently used methods for the studies of toxic effects of drug candidates. The detection of new biomolecular markers can shorten future studies.
Publikované
2006-01-15
Sekce
Články