Purine 8-O- and 8-S-cyclonucleosides - Synthesis and Properties

  • Z. Janeba Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague

Abstrakt

8-Cyclonucleosides derived from purine bases can be prepared by a number of reactions starting from appropriately modified nucleosides or their 8-substituted (most frequently bromo, hydroxy and sulfanyl) derivatives. The 8-cyclonucleosides are compounds suitable for studying configurations and conformations of purine nucleosides, also useful as intermediates in the synthesis of many biologically interesting compounds. Although the interest in 8-cyclonucleosides culminated in the sixties and seventies, many papers return to them at present and utilize them in various syntheses.
Publikované
2000-07-15
Sekce
Články