Determination of Antiarrhythmics and Their Metabolites in Clinical Samples Using a SPE-HPLC Combination

  • E. Brandsteterova Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovak Republic
  • A. Ferencova Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University, Bratislava, Slovak Republic

Abstrakt

An effective and simple SPE-HPLC assay for monitoring of clinically applied antiarrhythmics and their metabolites in serum samples was developed. In particular, the generally used SPE step has been modified for the clean-up and preconcentration procedure of clinical samples. Extraction recoveries for all analyzed compounds were in the range 81.4-90.7% for the concentration level m g.ml-1 of serum.
Publikované
1999-05-15
Sekce
Články