Katepsin B1 parazitické krevničky: molekulární cíl pro léčbu schistosomózy

  • A. Jílková Ústav organické chemie a biochemie Akademie věd České republiky, Praha
  • M. Horn Ústav organické chemie a biochemie Akademie věd České republiky, Praha
  • M. Mareš Ústav organické chemie a biochemie Akademie věd České republiky, Praha
Klíčová slova: katepsin, proteasa, proteolýza, schistosoma, parazit, inhibitor, chemoterapeutika, vakcína

Abstrakt

Schistosomiasis represents a global health problem with over 200 million people infected. It is caused by blood flukes of the genus Schistosoma that live in the human cardiovascular system, feeding on blood. Digestive protease cathepsin B1 of Schistosoma mansoni (SmCB1) plays a critical role in the proteolysis of host blood proteins and was identified as a target for chemotherapy of schistosomiasis. This review provides an update on function and structure of SmCB1, and novel intervention strategies against schistosomiasis based on SmCB1 inhibitors and vaccines.

Publikované
2018-01-15
Sekce
Články