Jak je to s náhodným objevem nových léčiv?

  • S. Rádl Zentiva, Praha
Klíčová slova: serendipity, náhodný objev, syntetická léčiva, fenolftalein, sulfonamidy, chlorpromazin, mechlorethamin, disulfiram, warfarin, sulfonylmočoviny, benzodiazepiny, cisplatina, omeprazol, chinolony, minoxidil, cyklosporin, metformin, sildenafil, acyklické nukleosidfosfonáty, terfenadin, fexofenadin, ibrutinib

Abstrakt

Serendipity is still one of the factors involved in drug discovery. Historically it has played a role in the discovery of a range of drugs that have had a great impact on the human therapy. This review presents 20 case studies of such serendipitous drug discoveries selected either for their importance in therapy or other interesting features. Of course, the selection is strictly subjective and many other examples could be added.

Publikované
2020-12-15
Sekce
Články