Molekulové formy cholínesteráz a ich kotviace proteíny
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the two enzymes that predominantly break down choline esters. The AChE gene produces four types of subunits based on alternative splicing; the BChE gene just one. The tailed AChE and BChE subunits form soluble oligomers and anchored hetero-oligomers. Hetero-oligomers are functional forms of cholinesterases in cholinergic synapses and at neuromuscular junctions. The hetero-oligomers consist of anchoring proteins and catalytic subunits held together by hydrophobic interactions. Cholinesterases anchored by collagen Q predominate in skeletal muscle while cholinesterase assambled with proline-rich membrane anchor are predominant in the nervous system.