Parallel Determination of Voriconazole and Posaconazole in Plasma by HPLC

  • L. Malášková Department of Clinical Biochemistry and Hematology,
  • J. Winterová Department of Internal Medicine and Hematooncology,
  • M. Dastych Department of Clinical Biochemistry and Hematology,
  • Z. Ráčil Department of Internal Medicine and Hematooncology,
  • I. Kocmanová Department of Clinical Microbiology, all University Hospital, Brno
  • M. Tošková Department of Clinical Biochemistry and Hematology,
  • J. Mayer Department of Internal Medicine and Hematooncology,

Abstrakt

Voriconazole and posaconazole are azole broad-spectrum pharmaceuticals used in treatment and prophylaxis of invasive fungal infections. Determination of both the antifungals in blood plasma in the course of treatment makes it possible to achieve optimal dosing. Our aim was to integrate voriconazole and posaconazole monitoring in the treatment of fungal infections in hematooncological patients. At present the simple and rapid ultra performance liquid chromatography (UPLC) monitoring of both the antifungals is a part of daily routine.
Publikované
2012-08-15
Sekce
Články