Synthesis and Biological Activity of 2- and 6-C-Substituted Purine Bases, Nucleosides and Acyclic Nucleotide Analogues (Bader Award Lecture)

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  • M. Hocek Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague

Abstrakt

An overview of the author's recent achievements in the synthesis 2- and 6-C-substituted purines. Diverse approaches consisting mainly in heterocyclization, nucleophilic substitution and cross-coupling reactions were applied to the preparation of the title purines which were further transformed to target nucleosides and nucleotide analogues. Biological activity of the analogues is discussed.

Publikováno

15.12.2000

Jak citovat

Hocek, M. (2000). Synthesis and Biological Activity of 2- and 6-C-Substituted Purine Bases, Nucleosides and Acyclic Nucleotide Analogues (Bader Award Lecture). Chemické Listy, 94(11). Získáno z http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/2467

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