Increasing Bioavailability of Poorly Water-Soluble Drugs by Technological Methods Facilitating Drug Dissolution

  • L. Okáčová Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno
  • D. Vetchý Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno
  • A. Franc Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno
  • M. Rabišková Department of Pharmaceutics, Faculty of Pharmacy, Veterinary and Pharmaceutical University, Brno

Abstrakt

The paper brings an overview of most important methods for attaining the purpose, such as solubilization using tensides, cosolvents, chelates, cyclodextrins, pH modifiers, interactive powder mixtures forming solid dispersions and microgranulates. The review summarizes main advantages and drawbacks of the methods and gives some examples. Although, the most frequently used technology in pharmaceutical industry is currently drug micronization, the above methods offer a well established way of enhancing solubility of drugs in water.
Publikované
2011-02-15
Sekce
Články