Study of Synthesis of 3'-Deoxy-3'-[18F]fluorothymidine – Prospective Radiopharmaceutical in Positron Emission Tomography

  • L. Procházka Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague
  • M. Kropáček Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague
  • M. Mirzajevová Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague
  • J. Zimová Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague
  • M. Försterová Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague
  • H. Švecová Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague
  • F. Melichar Nuclear Physics Institute, Academy of Sciences of the Czech Republic, Řež near Prague

Abstrakt

18F-Labelled compounds as active substances of radiopharmaceuticals are used for imaging in positron emission tomography (PET) in nuclear medicine. The radiosynthesis of PET radiopharmaceuticals is based on nucleophilic substitution with F? in a precursor. The synthesis is demonstrated on 3'-deoxy-3'-[18F]fluorothymidine.
Publikované
2008-12-15
Sekce
Články