Fucosidase and Fucose-Containing Glycoconjugates

  • E. Benešová Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • M. Marková Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • P. Lipovová Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague
  • B. Králová Department of Biochemistry and Microbiology, Institute of Chemical Technology, Prague

Abstrakt

α-L-fucosidase, an important exoglycosidase, is involved in the metabolism of fucose-containing glycoconjugates. The deficiency of the enzyme causes some incurable diseases, such as fucosidosis. Fucose-containing glycoconjugates are essential, as they are involved in several processes such as inflammation, reproduction, cell-cell interaction, signal transduction, growth regulation, and ligand-receptor interaction. The knowledge of fucosidase (its active site and catalytic mechanisms) and of fucose-containing glycoconjugates is not yet complete. At present, some uncomplicated methods for synthesis of fucose and fucose-containing glycoconjugates are sought, as the compounds can find some applications in therapy of severe diseases, such as cancer. For the synthesis of fucose-containing glycoconjugates, fucosidases with the ability to catalyze transglycosylation reaction can be used.
Publikované
2005-06-15
Sekce
Články