Synthesis, Kinetics, and Biological Activity of 2-Phenylquinazoline-4-thiones


  • J. Hanusek Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, 532 10 Pardubice


Derivatives of quinazolin-4-one and -4-thione are potential drugs. At present, about 25 preparations based on quinazolin-4-one are registered. An almost unexplored area is that of sulfur analogues of 2-(substituted phenyl)quinazolin-4-one derivatives, some of which also showing biological activity. Therefore, attention was focused on synthesis and biological activity of a series of mostly unpublished quinazolin-4-thione derivatives. The required 2-benzamidothiobenzamides were prepared by acylation of 2-aminothiobenzamide with benzoyl chlorides and subsequent cyclisation in basic medium. A detailed study of the cyclisation has revealed that its rate depends nonlinearly on concentration of the base used. Selected compounds have been tested for antialgal, antimycotic, and antitubeculotic activity.



Jak citovat

Hanusek, J. (2002). Synthesis, Kinetics, and Biological Activity of 2-Phenylquinazoline-4-thiones. Chemické Listy, 95(12). Získáno z