New Techniques in Diagnostics bv Capillary Electrophoresis of Hereditarv Disorders of Purine and Pvrimidine Metabolism

  • D. Friedecky Department of Analytical Chemistry, Palacký University, Olomouc,
  • T. Adam Centre of Analytical Chemistry of Molecular Structures, Palacky University, Olomouc
  • J. Sevcik Centre of Analytical Chemistry of Molecular Structures, Palacky University, Olomouc
  • P. Bartak Centre of Analytical Chemistry of Molecular Structures, Palacky University, Olomouc

Abstrakt

Purine and pyrimidine compounds were analyzed by capillary electrophoresis in urine of patients with inherited disorders purine and pyrimidine metabolism. Two separation of systems (alkaline-anionic and acid-cationic mode) have been compared. The use of a strongly acidic background electrolyte (pH 1.8) improves the selectivity and informative pithiness of the method. A combination of both anionic and cationic modes increases the reliability of diagnosis in hereditary disorders.
Publikované
1999-09-15
Sekce
Články