Syntetické modely metaloenzymů katalyzující štěpení fosfodiesterové vazby

  • D. Bím Ústav organické chemie, Vysoká škola chemicko-technologická v Praze, Praha | Ústav organické chemie a biochemie AV ČR, v.v.i., Praha
  • L. Rulíšek Ústav organické chemie a biochemie AV ČR, v.v.i., Praha
  • J. Hodačová Ústav organické chemie, Vysoká škola chemicko-technologická v Praze, Praha
Klíčová slova: syntetické modely fosfodiesteras, metaloenzymy, štěpení fosfoesterové vazby

Abstrakt

Phosphodiester bond cleavage is one of the most important processes in all living systems. Cell regulation is based on the effective and selective P–O bond cleavage, which is achieved by natural enzymes – phosphodiestera­ses. Some enzymes of this group rank among the most efficient known. The structure of these enzymes and their mechanism of action are important for designing the artificial enzyme models capable of catalyzing P–O bond cleavage. The present review summarizes the current approaches leading to synthesis of enzyme models and provides a comprehensive overview of the most important systems that have been synthesized and studied.

Publikované
2015-09-15
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