Pulsatile Drug Delivery Systems

Authors

  • D. Sabadková Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno
  • A. Franc Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno
  • J. Muselík Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno
  • D. Neumann Department of Pediatrics, University Hospital, Hradec Králové
  • D. Vetchý Department of Pharmaceutics, University of Veterinary and Pharmaceutical Sciences, Brno

Keywords:

drug delivery systems, pulsatile release, delayed release, circadian rhythm

Abstract

This review is focused on the basic principles of the delivery systems with a pulsatile release pattern. Such systems are designed according to the circadian rhythm of the body. Time-controlled, stimuli-induced and externally regulated pulsatile drug delivery systems are recognized. The drug release of time-controlled systems occurs after a predefined time lag. Stimuli-induced systems release the drug as a reaction to changeable conditions in the body (pH, glucose level). The drug release of externally regula­ted systems is controlled via external stimulus (magnetism, ultrasound). Pulsatile drug delivery systems rank among modern dosage forms which provide many therapeutic benefits.

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Published

2015-05-15

How to Cite

Sabadková, D., Franc, A., Muselík, J., Neumann, D., & Vetchý, D. (2015). Pulsatile Drug Delivery Systems. Chemické Listy, 109(5), 353–359. Retrieved from http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/369

Issue

Vol. 109 No. 5 (2015)

Section

Articles

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