Thermal Analysis in the Pharmaceutical Research and Drug Development

  • L. Seilerová Department of Solid State Chemistry, Institute of Chemical Technology, Prague,
  • H. Brusová Zentiva Co., Praha
  • B. Kratochvíl Department of Solid State Chemistry, Institute of Chemical Technology, Prague,
  • L. Krejčík Zentiva Co., Praha

Abstrakt

Thermal analysis is a valuable method in pharmaceutical research. A wide range of thermal methods are used in drug development like thermogravimetry (TG), diffe¬rential thermal analysis (DTA), differential scanning calori¬metry (DSC) and other sensitive and specific methods. The present review deals with application of these me¬thods in characterization of drugs and excipients, such as their polymorph stability, glass transition temperature, purity analysis and compatibility of drugs.
Publikované
2012-11-15
Sekce
Články