In Situ Monitoring of Asymmetric Transfer Hydrogenation of Imines Using NMR Spectrometry

  • J. Václavík Department of Organic Technology, Institute of Chemical Technology, Prague,
  • J. Pecháček Department of Organic Technology, Institute of Chemical Technology, Prague,
  • J. Přech Department of Organic Technology, Institute of Chemical Technology, Prague,
  • M. Kuzma Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
  • P. Kačer Department of Organic Technology, Institute of Chemical Technology, Prague,
  • L. Červený Department of Organic Technology, Institute of Chemical Technology, Prague,

Abstrakt

Three methods for determination of enantioselectivity of asymmetric transfer hydrogenation of imines are presented: direct NMR observation of diastereomeric reduction products of a chiral imine, chiral solvation with Pirkle’s alcohol, (-)-(1R)-1-(9-anthryl)-2,2,2-trifluoroethan-1-ol and precolumn derivatization with (-)-(1R)-menthyl chloroformate followed by GC analysis on a non-chiral column of the resulting diastereomeric carbamates.
Publikované
2012-04-15
Sekce
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