In Situ Monitoring of Asymmetric Transfer Hydrogenation of Imines Using NMR Spectrometry

Autoři

  • J. Václavík Department of Organic Technology, Institute of Chemical Technology, Prague,
  • J. Pecháček Department of Organic Technology, Institute of Chemical Technology, Prague,
  • J. Přech Department of Organic Technology, Institute of Chemical Technology, Prague,
  • M. Kuzma Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague
  • P. Kačer Department of Organic Technology, Institute of Chemical Technology, Prague,
  • L. Červený Department of Organic Technology, Institute of Chemical Technology, Prague,

Abstrakt

Three methods for determination of enantioselectivity of asymmetric transfer hydrogenation of imines are presented: direct NMR observation of diastereomeric reduction products of a chiral imine, chiral solvation with Pirkle’s alcohol, (-)-(1R)-1-(9-anthryl)-2,2,2-trifluoroethan-1-ol and precolumn derivatization with (-)-(1R)-menthyl chloroformate followed by GC analysis on a non-chiral column of the resulting diastereomeric carbamates.

Stahování

Publikováno

15.04.2012

Jak citovat

Václavík, J., Pecháček, J., Přech, J., Kuzma, M., Kačer, P., & Červený, L. (2012). In Situ Monitoring of Asymmetric Transfer Hydrogenation of Imines Using NMR Spectrometry. Chemické Listy, 106(3). Získáno z http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/966

Číslo

Vol 106 No 3 (2012)

Sekce

Články