Cardiac Glycosides: On Their Therapeutic Potential for Cancer Treatment

Authors

  • J. Bejček Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague
  • W. Spiwok Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague http://orcid.org/0000-0001-8108-2033
  • E. Kmoníčková Institute of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen http://orcid.org/0000-0002-0940-4605
  • T. Ruml Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague http://orcid.org/0000-0002-5698-4366
  • S. Rimpelová Department of Biochemistry and Microbiology, University of Chemistry and Technology, Prague http://orcid.org/0000-0002-3008-1396

Keywords:

digoxin, digitoxin, cardiac glycosides, ouabain, anticancer activity, natural compounds, sodium-potassium pump (Na⁺/K⁺-ATPase)

Abstract

Cardiac glycosides are bioactive natural compounds well-known mainly for their potency to induce a cardiotonic effect by sodium-potassium ATPase inhibition. For many years, cardiac glycosides have been utilized to treat heart failure and arrhythmias; however, according to novel research studies, these compounds have an enormous potential also as medicinally promising compounds for cancer treatment. The goal of this review is to provide a brief insight into the research topic of cardiac glycosides by describing their chemical structure, biosynthesis, the mechanism of action, anticancer potential alongside with the most significant clinical trials, as well as their other biological activities, such as the modulation of the immune system.

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Published

2021-01-15

How to Cite

Bejček, J., Spiwok, W., Kmoníčková, E., Ruml, T., & Rimpelová, S. (2021). Cardiac Glycosides: On Their Therapeutic Potential for Cancer Treatment. Chemické Listy, 115(1), 4–12. Retrieved from http://www.chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3766

Issue

Vol. 115 No. 1 (2021)

Section

Articles